Move tempdb files to a different location.
USE MASTER GO ALTER DATABASE tempdb MODIFY FILE (name = tempdev, filename = 'D:\Path\To\tempdatafile.mdf') GO ALTER DATABASE tempdb MODIFY FILE (name = templog, filename = 'L:\Path\To\templogfile.ldf') GO
Restart the database engine and check if the new files are created. For more information on file locations you can use the stored procedure sp_helpfile. Remove the files from the original location.